1 Analysis of the N - terminal region of human MLKL
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© 2015 The Author(s) Archiving permitted only in line with the archiving policy of Portland Press Limited. The final version of record will be available under the Creative Commons Attribution Licence 3.0 (http://creativecommons.org/licenses/by/3.0/). You are encouraged to use the final version of record. A C C E P T E D M A N U S C R IP T 10.1042/BSR20150246 . Please cite using the DOI 10.1042/BSR20150246 http://dx.doi.org/ up-to-date version is available at encouraged to use the Version of Record that, when published, will replace this version. The most this is an Accepted Manuscript, not the final Version of Record. You are : Bioscience Reports
منابع مشابه
Analysis of the N-terminal region of human MLKL, as well as two distinct MLKL isoforms, reveals new insights into necroptotic cell death
The pseudokinase mixed lineage kinase domain-like (MLKL) is an essential effector of necroptotic cell death. Two distinct human MLKL isoforms have previously been reported, but their capacities to trigger cell death have not been compared directly. Herein, we examine these two MLKL isoforms, and further probe the features of the human MLKL N-terminal domain that are required for cell death. Exp...
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Background: MLKL, one of the main downstream components of the necroptosis or programmed necrosis has recently been demonstrated in advanced atherosclerotic lesions. However, its precise role in the atherosclerosis pathogenesis still requires more elucidation. Our study was set to delineate both the changes in peripheral MLKL gene expression and its influence on disease severity in atherosclero...
متن کامل1 Analysis of the N - terminal region of human MLKL , as well as two
© 2015 The Author(s) Archiving permitted only in line with the archiving policy of Portland Press Limited. The final version of record will be available under the Creative Commons Attribution Licence 3.0 (http://creativecommons.org/licenses/by/3.0/). You are encouraged to use the final version of record. A C C E P T E D M A N U S C R IP T 10.1042/BSR20150246 . Please cite using the DOI 10.1042/...
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Although mixed lineage kinase domain-like (MLKL) protein has emerged as a specific and crucial protein for necroptosis induction, how MLKL transduces the death signal remains poorly understood. Here, we demonstrate that the full four-helical bundle domain (4HBD) in the N-terminal region of MLKL is required and sufficient to induce its oligomerization and trigger cell death. Moreover, we found t...
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